As U.S. troops leave Afghanistan, the regional landscape that has dominated the last two decades of U.S.-Pakistan relations is shifting significantly. The Biden administration’s focus on competition with China and increasing climate concerns — coupled with the Pakistani government’s desire to shift focus to geo-economic ties with the United States — offer potential new parameters for the U.S.-Pakistan relationship. Meanwhile, both countries remain vested in the outcome of the Afghan peace process and regional peace and security in South Asia. Can the United States and Pakistan move beyond the persistent challenges in the bilateral relationship to cooperate on the priorities they share?